Tumor necrosis factor (TNF) inhibits interleukin (IL)-1 and/or IL-6 stimulated synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of …
SH Yap, HJ Moshage, BPC Hazenberg… - … et Biophysica Acta (BBA …, 1991 - Elsevier
Abstract Interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF) are considered as important
mediators for the modulation of liver synthesis of acute phase proteins. However, studies of
the direct effect of individual or a combination of these cytokines on the synthesis of acute
phase proteins in human hepatocytes are still very limited. In this study, we have examined
the synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of
human hepatocytes exposed to recombinant (r) IL-1α (100 U/ml), rIL-6 (2000 U/ml), rTNFα …
mediators for the modulation of liver synthesis of acute phase proteins. However, studies of
the direct effect of individual or a combination of these cytokines on the synthesis of acute
phase proteins in human hepatocytes are still very limited. In this study, we have examined
the synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of
human hepatocytes exposed to recombinant (r) IL-1α (100 U/ml), rIL-6 (2000 U/ml), rTNFα …
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