Tumor-infiltrating lymphocytes (TILs) from patients with glioma

Z Liu, Q Meng, J Bartek Jr, T Poiret, O Persson… - …, 2017 - Taylor & Francis
Tumor-infiltrating lymphocytes (TILs) may represent a viable source of T cells for the
biological treatment of patients with gliomas. Glioma tissue was obtained from 16 patients,
tumor cell lines were established, and TILs were expanded in 16/16 cases using a
combination of IL-2/IL-15/IL-21. Intracellular cytokine staining (ICS, IL-2, IL-17, TNFα and
IFNγ production) as well as a cytotoxicity assay was used to detect TIL reactivity against
autologous tumor cells or shared tumor-associated antigens (TAAs; ie, NY-ESO-1, Survivin …

[引用][C] Tumor-infiltrating lymphocytes (TILs) from patients with glioma. OncoImmunology. 2016; 6: e1252894

Z Liu, Q Meng, J Bartek Jr, T Poiret, O Persson, L Rane
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