Two new bioactive diterpenes identified from Isodon interruptus
Bioorganic Chemistry, 2020•Elsevier
In the course of our ongoing studies to discover bioactive chemical constituents from plants
in the genus Isodon, two new diterpenes, kunminolide A (1) and rabdokunmin F (2) were
isolated from the leaves of the medicinal plant Isodon interruptus. Kunminolide A (1) is a
novel abietane-like diterpene with a novel skeleton, herein designated as 9, 10-seco-
neoabietane. Rabdokunmin F (2) is an ent-kaurene diterpene with C-18 oxidized to a
carboxylic acid group. The structures were determined by spectroscopic means including …
in the genus Isodon, two new diterpenes, kunminolide A (1) and rabdokunmin F (2) were
isolated from the leaves of the medicinal plant Isodon interruptus. Kunminolide A (1) is a
novel abietane-like diterpene with a novel skeleton, herein designated as 9, 10-seco-
neoabietane. Rabdokunmin F (2) is an ent-kaurene diterpene with C-18 oxidized to a
carboxylic acid group. The structures were determined by spectroscopic means including …
Abstract
In the course of our ongoing studies to discover bioactive chemical constituents from plants in the genus Isodon, two new diterpenes, kunminolide A (1) and rabdokunmin F (2) were isolated from the leaves of the medicinal plant Isodon interruptus. Kunminolide A (1) is a novel abietane-like diterpene with a novel skeleton, herein designated as 9, 10-seco-neoabietane. Rabdokunmin F (2) is an ent-kaurene diterpene with C-18 oxidized to a carboxylic acid group. The structures were determined by spectroscopic means including analysis of 1D- and 2D-NMR spectral data. Crystals of 1 obtained from methanol were suitable for X-ray analysis, which confirmed the chemical structure. Kunminolide A (1) demonstrated chemopreventive potential by inducing QR1 activity with a CD value of 14.3 µM, and rabdokunmin F (2) was found to have cytotoxic activities with IC50 values in the range of 1.1–3.0 µM.
Elsevier
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