Tyrosol, an olive oil polyphenol, inhibits ER stress-induced apoptosis in pancreatic β-cell through JNK signaling
Dysfunction of pancreatic β-cell is a major determinant for the development of type 2
diabetes. Because of the stimulated insulin secretion in metabolic syndrome, endoplasmic
reticulum (ER) stress plays a central mediator for β-cell failure. In this study, we investigated
whether an antioxidant phenolic compound, tyrosol protects against β-cell dysfunction
associated with ER stress. To address this issue, we exposed pancreatic β cells, NIT-1 to
tunicamycin with tyrosol. We found tyrosol diminished tunicamycin-induced cell death in a …
diabetes. Because of the stimulated insulin secretion in metabolic syndrome, endoplasmic
reticulum (ER) stress plays a central mediator for β-cell failure. In this study, we investigated
whether an antioxidant phenolic compound, tyrosol protects against β-cell dysfunction
associated with ER stress. To address this issue, we exposed pancreatic β cells, NIT-1 to
tunicamycin with tyrosol. We found tyrosol diminished tunicamycin-induced cell death in a …
Tyrosol, an olive oil polyphenol, inhibits ER stress-induced apoptosis in pancreatic β-cell through JNK signaling.
LHJ Lee HyunJung, ISW Im SungWon… - 2016 - cabidigitallibrary.org
Dysfunction of pancreatic β-cell is a major determinant for the development of type 2
diabetes. Because of the stimulated insulin secretion in metabolic syndrome, endoplasmic
reticulum (ER) stress plays a central mediator for β-cell failure. In this study, we investigated
whether an antioxidant phenolic compound, tyrosol protects against β-cell dysfunction
associated with ER stress. To address this issue, we exposed pancreatic β cells, NIT-1 to
tunicamycin with tyrosol. We found tyrosol diminished tunicamycin-induced cell death in a …
diabetes. Because of the stimulated insulin secretion in metabolic syndrome, endoplasmic
reticulum (ER) stress plays a central mediator for β-cell failure. In this study, we investigated
whether an antioxidant phenolic compound, tyrosol protects against β-cell dysfunction
associated with ER stress. To address this issue, we exposed pancreatic β cells, NIT-1 to
tunicamycin with tyrosol. We found tyrosol diminished tunicamycin-induced cell death in a …
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