UGT1A1*28 Variant Allele Is a Predictor of Severe Hyperbilirubinemia in HIV-Infected Patients on HAART in Southern Brazil
L Turatti, E Sprinz, RK Lazzaretti… - AIDS research and …, 2012 - liebertpub.com
Highly active antiretroviral therapy (HAART) has increased the survival of HIV-infected
patients. However, adverse effects play a major role in adherence to HAART. Some
protease inhibitors (mainly atazanavir and indinavir) act as inhibitors of uridine diphosphate-
glucuronosyltransferase (UGT1A1), the enzyme responsible for hepatic conjugation of
bilirubin. Variations in the promoter region of the UGT1A1 gene (UGT1A1* 28, rs8175347)
can influence bilirubin plasma levels, modulating the susceptibility to hyperbilirubinemia …
patients. However, adverse effects play a major role in adherence to HAART. Some
protease inhibitors (mainly atazanavir and indinavir) act as inhibitors of uridine diphosphate-
glucuronosyltransferase (UGT1A1), the enzyme responsible for hepatic conjugation of
bilirubin. Variations in the promoter region of the UGT1A1 gene (UGT1A1* 28, rs8175347)
can influence bilirubin plasma levels, modulating the susceptibility to hyperbilirubinemia …
UGT1A1* 28 variant allele is a predictor of severe hyperbilirubinemia in HIV-infected patients on HAART in Southern Brazil
LT Cason, E Sprinz, RK Lazzaretti… - AIDS research and …, 2012 - lume.ufrgs.br
Highly active antiretroviral therapy (HAART) has increased the survival of HIV-infected
patients. However, adverse effects play a major role in adherence to HAART. Some
protease inhibitors (mainly atazanavir and indinavir) act as inhibitors of uridine diphosphate-
glucuronosyltransferase (UGT1A1), the enzyme responsible for hepatic conjugation of
bilirubin. Variations in the promoter region of the UGT1A1 gene (UGT1A1* 28, rs8175347)
can influence bilirubin plasma levels, modulating the susceptibility to hyperbilirubinemia …
patients. However, adverse effects play a major role in adherence to HAART. Some
protease inhibitors (mainly atazanavir and indinavir) act as inhibitors of uridine diphosphate-
glucuronosyltransferase (UGT1A1), the enzyme responsible for hepatic conjugation of
bilirubin. Variations in the promoter region of the UGT1A1 gene (UGT1A1* 28, rs8175347)
can influence bilirubin plasma levels, modulating the susceptibility to hyperbilirubinemia …
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