… of mechanisms that support protein trafficking and secretion. This Research Topic of 18
articles explores the general topic of UPS by covering basic mechanisms, their dysregulation in …

… signals for secretion of signal sequence lacking proteins (… of mechanisms that support
protein trafficking and secretion. … of UPS by covering basic mechanisms, their dysregulation in …

… promise for the treatment of neurodegenerative diseases, although the development and …
mechanisms of intercellular communication and enhance our understanding of various disease …

… cargo secreted through this unconventional route, and describe the implications of this pathway
in both health and disease. … Dysregulation of these cells is one feature of Crohn disease. …

… several mechanisms to ensure secretory protein quality … quality control dysregulation
and diverse human pathologies… diseases, we could observe neuronal loss and proteins …

… Here, we summarize mechanisms for detecting and … treat human diseases, including
neurodegenerative disorders and … bZip transcription factors through unconventional mRNA …

… transcriptional mechanisms, the UPR upregulates the protein … mRNA and initiates an
unconventional splicing reaction, … to treat complex metabolic diseases associated with chronic …

… diseases. Here, we review the recent literature on cellular … Dysregulation of the tau–MT
complex leads to tau detachment … -terminal part of the protein, and alternative splicing of exons 2 …

… is secreted by neurons through unconventional secretory … , increased Tau secretion and that
secreted Tau was cleaved … whether the increase of Tau secretion by VAMP8 affected its intra-…