Under-enrollment of obese heart failure with preserved ejection fraction patients in major HFpEF clinical trials
Background Therapy for heart failure with preserved ejection fraction (HFpEF) remains an
unmet need with lack of a consensus definition of HFpEF for inclusion into clinical trials. We
evaluated whether hemodynamically characterized patients from a HFpEF referral center
met inclusion criteria for 4 major HFpEF trials. Methods and Results Patients were assessed
for theoretical inclusion into 4 major clinical trials (I-PRESERVE, RELAX, TOPCAT, and
PARAGON-HF). Clinical, echocardiographic and hemodynamic characteristics and …
unmet need with lack of a consensus definition of HFpEF for inclusion into clinical trials. We
evaluated whether hemodynamically characterized patients from a HFpEF referral center
met inclusion criteria for 4 major HFpEF trials. Methods and Results Patients were assessed
for theoretical inclusion into 4 major clinical trials (I-PRESERVE, RELAX, TOPCAT, and
PARAGON-HF). Clinical, echocardiographic and hemodynamic characteristics and …
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