Understanding the constitutive presentation of MHC class I immunopeptidomes in primary tissues
P Kubiniok, A Marcu, L Bichmann, L Kuchenbecker… - Iscience, 2022 - cell.com
Understanding the molecular principles that govern the composition of the MHC-I
immunopeptidome across different primary tissues is fundamentally important to predict how
T cells respond in different contexts in vivo. Here, we performed a global analysis of the
MHC-I immunopeptidome from 29 to 19 primary human and mouse tissues, respectively.
First, we observed that different HLA-A, HLA-B, and HLA-C allotypes do not contribute
evenly to the global composition of the MHC-I immunopeptidome across multiple human …
immunopeptidome across different primary tissues is fundamentally important to predict how
T cells respond in different contexts in vivo. Here, we performed a global analysis of the
MHC-I immunopeptidome from 29 to 19 primary human and mouse tissues, respectively.
First, we observed that different HLA-A, HLA-B, and HLA-C allotypes do not contribute
evenly to the global composition of the MHC-I immunopeptidome across multiple human …
[引用][C] Understanding the constitutive presentation of MHC class I immunopeptidomes in primary tissues. iScience 25
P Kubiniok, A Marcu, L Bichmann, L Kuchenbecker… - 2022
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