[HTML][HTML] Unlocking Fungal Potential: The CRISPR-Cas System as a Strategy for Secondary Metabolite Discovery
Natural products (NPs) are crucial for the development of novel antibiotics, anticancer
agents, and immunosuppressants. To highlight the ability of fungi to produce structurally
diverse NPs, this article focuses on the impact of genome mining and CRISPR-Cas9
technology in uncovering and manipulating the biosynthetic gene clusters (BGCs)
responsible for NP synthesis. The CRISPR-Cas9 system, originally identified as a bacterial
adaptive immune mechanism, has been adapted for precise genome editing in fungi …
agents, and immunosuppressants. To highlight the ability of fungi to produce structurally
diverse NPs, this article focuses on the impact of genome mining and CRISPR-Cas9
technology in uncovering and manipulating the biosynthetic gene clusters (BGCs)
responsible for NP synthesis. The CRISPR-Cas9 system, originally identified as a bacterial
adaptive immune mechanism, has been adapted for precise genome editing in fungi …
Unlocking Fungal Potential: The CRISPR-Cas System as a Strategy for Secondary Metabolite Discovery
K Leal Villegas, E Rojas, D Madariaga… - Journal of …, 2024 - repositorio.uautonoma.cl
Natural products (NPs) are crucial for the development of novel antibiotics, anticancer
agents, and immunosuppressants. To highlight the ability of fungi to produce structurally
diverse NPs, this article focuses on the impact of genome mining and CRISPR-Cas9
technology in uncovering and manipulating the biosynthetic gene clusters (BGCs)
responsible for NP synthesis. The CRISPR-Cas9 system, originally identified as a bacterial
adaptive immune mechanism, has been adapted for precise genome editing in fungi …
agents, and immunosuppressants. To highlight the ability of fungi to produce structurally
diverse NPs, this article focuses on the impact of genome mining and CRISPR-Cas9
technology in uncovering and manipulating the biosynthetic gene clusters (BGCs)
responsible for NP synthesis. The CRISPR-Cas9 system, originally identified as a bacterial
adaptive immune mechanism, has been adapted for precise genome editing in fungi …
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