Unraveling structural insights of ribokinase from Leishmania donovani
Ribokinase (RK) is an ATP dependent sugar kinase that enables the entry of ribose in the
metabolism. Leishmania accumulates ribose into the cytosol through hydrolysis of
nucleosides and by transport from the extracellular environment. Activation by RK is critical
to mobilize the ribose into the metabolism of Leishmania. To understand the catalytic role,
the crystal structure of RK (LdRK) from L. donovani was determined in the apo and complex
forms with several nucleotides (ATP, AMPPCP and ADP) in the presence of Na+ ion. The …
metabolism. Leishmania accumulates ribose into the cytosol through hydrolysis of
nucleosides and by transport from the extracellular environment. Activation by RK is critical
to mobilize the ribose into the metabolism of Leishmania. To understand the catalytic role,
the crystal structure of RK (LdRK) from L. donovani was determined in the apo and complex
forms with several nucleotides (ATP, AMPPCP and ADP) in the presence of Na+ ion. The …
Unraveling structural insights of ribokinase from Leishmania donovani.
SG Santhosh Gatreddi, VP Vijaykumar Pillalamarri… - 2019 - cabidigitallibrary.org
Ribokinase (RK) is an ATP dependent sugar kinase that enables the entry of ribose in the
metabolism. Leishmania accumulates ribose into the cytosol through hydrolysis of
nucleosides and by transport from the extracellular environment. Activation by RK is critical
to mobilize the ribose into the metabolism of Leishmania. To understand the catalytic role,
the crystal structure of RK (Ld RK) from L. donovani was determined in the apo and complex
forms with several nucleotides (ATP, AMPPCP and ADP) in the presence of Na+ ion. The …
metabolism. Leishmania accumulates ribose into the cytosol through hydrolysis of
nucleosides and by transport from the extracellular environment. Activation by RK is critical
to mobilize the ribose into the metabolism of Leishmania. To understand the catalytic role,
the crystal structure of RK (Ld RK) from L. donovani was determined in the apo and complex
forms with several nucleotides (ATP, AMPPCP and ADP) in the presence of Na+ ion. The …
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