Update on ischemia-reperfusion injury in lung transplantation

F Chen, H Date - Current opinion in organ transplantation, 2015 - journals.lww.com
Current opinion in organ transplantation, 2015journals.lww.com
… IRI may also induce rejection, which is the principal cause of mortality after
transplantation. It is essential to understand the mechanism of pulmonary IRI for improving
the outcomes of lung transplantation, and therefore we reviewed the state of the art
concerning pulmonary IRI in lung transplantation. … Ischemia-reperfusion injury (IRI) is a
multifaceted pathological process that complicates the perioperative management of
patients undergoing lung transplantation (Fig. 1). The most severe form may lead to primary …
Summary
IRI, whose pathophysiology remains incompletely understood, is one of the most critical phenomena in lung transplantation, and therefore more studies to control pulmonary IRI are required for improving the outcomes of lung transplantation.
Lippincott Williams & Wilkins
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