Use of Ribosome-Inactivating Proteins from Sambucus for the Construction of Immunotoxins and Conjugates for Cancer Therapy
The type 2 ribosome-inactivating proteins (RIPs) isolated from some species belonging to
the Sambucus genus, have the characteristic that although being even more active than ricin
inhibiting protein synthesis in cell-free extracts, they lack the high toxicity of ricin and related
type 2 RIPs to intact cells and animals. This is due to the fact that after internalization, they
follow a different intracellular pathway that does not allow them to reach the cytosolic
ribosomes. The lack of toxicity of type 2 RIPs from Sambucus make them good candidates …
the Sambucus genus, have the characteristic that although being even more active than ricin
inhibiting protein synthesis in cell-free extracts, they lack the high toxicity of ricin and related
type 2 RIPs to intact cells and animals. This is due to the fact that after internalization, they
follow a different intracellular pathway that does not allow them to reach the cytosolic
ribosomes. The lack of toxicity of type 2 RIPs from Sambucus make them good candidates …
Use of ribosome-inactivating proteins from Sambucus for the construction of immunotoxins and conjugates for cancer therapy
JM Ferreras Rodríguez, L Citores González… - 2011 - uvadoc.uva.es
The type 2 ribosome-inactivating proteins (RIPs) isolated from some species belonging to
the Sambucus genus, have the characteristic that although being even more active than ricin
inhibiting protein synthesis in cell-free extracts, they lack the high toxicity of ricin and related
type 2 RIPs to intact cells and animals. This is due to the fact that after internalization, they
follow a different intracellular pathway that does not allow them to reach the cytosolic
ribosomes. The lack of toxicity of type 2 RIPs from Sambucus make them good candidates …
the Sambucus genus, have the characteristic that although being even more active than ricin
inhibiting protein synthesis in cell-free extracts, they lack the high toxicity of ricin and related
type 2 RIPs to intact cells and animals. This is due to the fact that after internalization, they
follow a different intracellular pathway that does not allow them to reach the cytosolic
ribosomes. The lack of toxicity of type 2 RIPs from Sambucus make them good candidates …
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