There is great concern in Africa and the world in general about the loss of biodiversity that calls for more conservation efforts. At current time of hope for peace in the Democratic Republic of Congo (DRC), in the immediate aftermath of devastating civil strife, the scale of wildlife loss and degradation is a major looming threat to the Itombwe massif's biodiversity. This paper highlights potential threats from human activity and outlines a conceptual methodology to support conservation of critically endangered grauer's gorilla in the Itombwe massif by using Geographic Information Systems (GIS) applications. Evaluation of threats from human activity with respect to the conservation of the Massif and its populations of gorilla, Gorilla beringei graueri (the type specimen of this subspecies came from the region) as well as eastern chimpanzees (Pan troglodytes schweinfurthi), is among the most important conservation priorities as far as the DRC is concerned.