A fully automated on-line solid-phase extraction–liquid chromatography–tandem mass
spectrometry (SPE–LC–MS/MS) method has been developed for the determination of 13
cytostatics and 4 metabolites in aqueous matrices, including groundwater, surface water,
and raw and treated wastewater. On-line SPE is performed by loading 5mL of water sample
at pH 2 through a PLRP-s cartridge. MS/MS is performed with an electrospray (ESI) interface
operating in the positive ion mode and registering two selected reaction monitoring (SRM) …

The use of pesticides to protect crops against plagues and insects is one of the most
important ways to assure agricultural quality and productivity. However, bad application
practices may cause the contamination of different environmental compartments and animal
species, as a consequence of migration or accumulation of those compounds. Fipronil,
imidacloprid and thiametoxam are systemic or systemic-like insecticides widely used in
maize crops. Their heavy action in the nervous system of target insects also means a high …