Validation of cardiac diffusion tensor MRI using transparent tissue preparation (CLARITY) with 3D optical microscopy
The myocardium consists of a complex 3-dimensional (3D) microstructure has been shown
to be perturbed in the presence of myocardial ischemia. Recently, diffusion tensor magnetic
resonance imaging (DT-CMR) was introduced which can characterize the 3D tissue
microstructure in intact myocardium. However, past histologic validation of DTI has been
limited since traditional pathology allows only 2D optical microscopy after potentially
destructive tissue sectioning. We present a novel approach to validate the derivation of the …
to be perturbed in the presence of myocardial ischemia. Recently, diffusion tensor magnetic
resonance imaging (DT-CMR) was introduced which can characterize the 3D tissue
microstructure in intact myocardium. However, past histologic validation of DTI has been
limited since traditional pathology allows only 2D optical microscopy after potentially
destructive tissue sectioning. We present a novel approach to validate the derivation of the …
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