Vanadium compounds induced mitochondria permeability transition pore (PTP) opening related to oxidative stress
Y Zhao, L Ye, H Liu, Q Xia, Y Zhang, X Yang… - Journal of inorganic …, 2010 - Elsevier
Vanadium compounds have been regarded as promising in therapeutic treatment of
diabetes and in cancer prevention. In the present work, we studied the effects of vanadium
compounds on mitochondria to investigate the mechanisms of toxicity. Mitochondria were
isolated from rat liver and incubated with a variety of vanadium compounds, ie VOSO4,
NaVO3, and vanadyl complexes with organic ligands. Our studies indicated that VO2+, VO3-
, VO (acac) 2 and VOcit (1–100μM) could induce mitochondrial swelling in a concentration …
diabetes and in cancer prevention. In the present work, we studied the effects of vanadium
compounds on mitochondria to investigate the mechanisms of toxicity. Mitochondria were
isolated from rat liver and incubated with a variety of vanadium compounds, ie VOSO4,
NaVO3, and vanadyl complexes with organic ligands. Our studies indicated that VO2+, VO3-
, VO (acac) 2 and VOcit (1–100μM) could induce mitochondrial swelling in a concentration …
Vanadium compounds induced mitochondria permeability transition pore (PTP) opening related to oxidative stress.
ZYB Zhao YueBin, YLH Ye LiHua, LHX Liu HuiXue… - 2010 - cabidigitallibrary.org
Vanadium compounds have been regarded as promising in therapeutic treatment of
diabetes and in cancer prevention. In the present work, we studied the effects of vanadium
compounds on mitochondria to investigate the mechanisms of toxicity. Mitochondria were
isolated from rat liver and incubated with a variety of vanadium compounds, ie VOSO4,
NaVO3, and vanadyl complexes with organic ligands. Our studies indicated that VO2+, VO3-
, VO (acac) 2 and VOcit (1-100 µM) could induce mitochondrial swelling in a concentration …
diabetes and in cancer prevention. In the present work, we studied the effects of vanadium
compounds on mitochondria to investigate the mechanisms of toxicity. Mitochondria were
isolated from rat liver and incubated with a variety of vanadium compounds, ie VOSO4,
NaVO3, and vanadyl complexes with organic ligands. Our studies indicated that VO2+, VO3-
, VO (acac) 2 and VOcit (1-100 µM) could induce mitochondrial swelling in a concentration …
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