Vascular Calcification Induced by Chronic Kidney Disease Is Mediated by an Increase of 1α‐Hydroxylase Expression in Vascular Smooth Muscle Cells
N Torremadé, M Bozic, S Panizo… - Journal of Bone and …, 2016 - academic.oup.com
Vascular calcification (VC) is a complication of chronic kidney disease that predicts morbidity
and mortality. Uremic serum promotes VC, but the mechanism involved is unknown. A role
for 1, 25 (OH) 2D3 in VC has been proposed, but the mechanism is unclear because both
low and high levels have been shown to increase it. In this work we investigate the role of 1,
25 (OH) 2D3 produced in vascular smooth muscle cells (VSMCs) in VC. Rats with subtotal
nephrectomy and kidney recipient patients showed increased arterial expression of 1α …
and mortality. Uremic serum promotes VC, but the mechanism involved is unknown. A role
for 1, 25 (OH) 2D3 in VC has been proposed, but the mechanism is unclear because both
low and high levels have been shown to increase it. In this work we investigate the role of 1,
25 (OH) 2D3 produced in vascular smooth muscle cells (VSMCs) in VC. Rats with subtotal
nephrectomy and kidney recipient patients showed increased arterial expression of 1α …
[PDF][PDF] Vascular calcification induced by chronic kidney disease is mediated by an increase of 1α-hydroxylase expression in vascular smooth muscle cells
N Torremadé Pascual, M Bozic, S Panizo García… - 2016 - repositori.udl.cat
Vascular calcification (VC) is a complication of chronic kidney disease which predicts
morbidity and mortality. Uremic serum promotes VC, but the mechanism involved is
unknown. A role for 1, 25 (OH) 2D3 on VC has been proposed, but the mechanism is
unclear because both, low and high levels have been shown to increase it. In this paper we
investigate the role of 1, 25 (OH) 2D3 produced in vascular smooth muscle cells (VSMCs) on
VC. Rats with subtotal nephrectomy and kidney recipient patients showed increased arterial …
morbidity and mortality. Uremic serum promotes VC, but the mechanism involved is
unknown. A role for 1, 25 (OH) 2D3 on VC has been proposed, but the mechanism is
unclear because both, low and high levels have been shown to increase it. In this paper we
investigate the role of 1, 25 (OH) 2D3 produced in vascular smooth muscle cells (VSMCs) on
VC. Rats with subtotal nephrectomy and kidney recipient patients showed increased arterial …
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