Vesicle-associated membrane protein 3 (VAMP3) mediates constitutive trafficking of the renal co-transporter NKCC2 in thick ascending limbs: role in renal function …
Renal cells of the thick ascending limb (TAL) reabsorb NaCl via the apical Na+/K+/2Cl− co-
transporter NKCC2. Trafficking of NKCC2 to the apical surface regulates NKCC2-mediated
NaCl absorption and blood pressure. The molecular mechanisms by which NKCC2 reaches
the apical surface and their role in renal function and maintenance of blood pressure are
poorly characterized. Here we report that NKCC2 interacts with the vesicle fusion protein
VAMP3, and they co-localize at the TAL apical surface. We observed that silencing VAMP3 …
transporter NKCC2. Trafficking of NKCC2 to the apical surface regulates NKCC2-mediated
NaCl absorption and blood pressure. The molecular mechanisms by which NKCC2 reaches
the apical surface and their role in renal function and maintenance of blood pressure are
poorly characterized. Here we report that NKCC2 interacts with the vesicle fusion protein
VAMP3, and they co-localize at the TAL apical surface. We observed that silencing VAMP3 …
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