[HTML][HTML] Visual attention deficits in schizophrenia can arise from inhibitory dysfunction in thalamus or cortex
Schizophrenia is associated with diverse cognitive deficits, including disorders of attention-
related oculomotor behavior. At the structural level, schizophrenia is associated with
abnormal inhibitory control in the circuit linking cortex and thalamus. We developed a
spiking neural network model that demonstrates how dysfunctional inhibition can degrade
attentive gaze control. Our model revealed that perturbations of two functionally distinct
classes of cortical inhibitory neurons, or of the inhibitory thalamic reticular nucleus, disrupted …
related oculomotor behavior. At the structural level, schizophrenia is associated with
abnormal inhibitory control in the circuit linking cortex and thalamus. We developed a
spiking neural network model that demonstrates how dysfunctional inhibition can degrade
attentive gaze control. Our model revealed that perturbations of two functionally distinct
classes of cortical inhibitory neurons, or of the inhibitory thalamic reticular nucleus, disrupted …
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