Visualizing changes in Cdkn1c expression links early-life adversity to imprint mis-regulation in adults
M Van de Pette, A Abbas, A Feytout, G McNamara… - Cell reports, 2017 - cell.com
Imprinted genes are regulated according to parental origin and can influence embryonic
growth and metabolism and confer disease susceptibility. Here, we designed sensitive allele-
specific reporters to non-invasively monitor imprinted Cdkn1c expression in mice and
showed that expression was modulated by environmental factors encountered in utero.
Acute exposure to chromatin-modifying drugs resulted in de-repression of paternally
inherited (silent) Cdkn1c alleles in embryos that was temporary and resolved after birth. In …
growth and metabolism and confer disease susceptibility. Here, we designed sensitive allele-
specific reporters to non-invasively monitor imprinted Cdkn1c expression in mice and
showed that expression was modulated by environmental factors encountered in utero.
Acute exposure to chromatin-modifying drugs resulted in de-repression of paternally
inherited (silent) Cdkn1c alleles in embryos that was temporary and resolved after birth. In …
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