Besides intrinsic changes, malignant cells also release soluble signals that reshape their
microenvironment. Among these signals is WNT1-inducible signaling pathway protein 1
(WISP1), a secreted matricellular protein whose expression is elevated in several cancers,
including melanoma, and is associated with reduced survival of patients diagnosed with
primary melanoma. Here, we found that WISP1 knockout increases cell proliferation and
represses wound healing, migration, and invasion of mouse and human melanoma cells in …