Weathering the COVID-19 storm: lessons from hematologic cytokine syndromes
A subset of patients with severe COVID-19 develop profound inflammation and multi-organ
dysfunction consistent with a “Cytokine Storm Syndrome”(CSS). In this review we compare
the clinical features, diagnosis, and pathogenesis of COVID-CSS with other hematological
CSS, namely secondary hemophagocytic lymphohistiocytosis (sHLH), idiopathic multicentric
Castleman disease (iMCD), and CAR-T cell therapy associated Cytokine Release
Syndrome (CRS). Novel therapeutics targeting cytokines or inhibiting cell signaling …
dysfunction consistent with a “Cytokine Storm Syndrome”(CSS). In this review we compare
the clinical features, diagnosis, and pathogenesis of COVID-CSS with other hematological
CSS, namely secondary hemophagocytic lymphohistiocytosis (sHLH), idiopathic multicentric
Castleman disease (iMCD), and CAR-T cell therapy associated Cytokine Release
Syndrome (CRS). Novel therapeutics targeting cytokines or inhibiting cell signaling …
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