Win-paired cues modulate the effect of dopamine neuron sensitization on decision making and cocaine self-administration: divergent effects across sex
Background Both psychostimulant use and engagement with probabilistic schedules of
reward sensitize the mesocorticolimbic dopamine (DA) system. Such behaviors may act
synergistically to explain the high comorbidity between stimulant use and gambling disorder.
The salient audiovisual stimuli of modern electronic gambling may exacerbate the situation.
Methods To probe these interactions, we sensitized ventral tegmental area DA neurons via
chronic chemogenetic stimulation while rats (n= 134) learned a rat gambling task in the …
reward sensitize the mesocorticolimbic dopamine (DA) system. Such behaviors may act
synergistically to explain the high comorbidity between stimulant use and gambling disorder.
The salient audiovisual stimuli of modern electronic gambling may exacerbate the situation.
Methods To probe these interactions, we sensitized ventral tegmental area DA neurons via
chronic chemogenetic stimulation while rats (n= 134) learned a rat gambling task in the …
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