cotransporter (NCC) along the distal convoluted tubule, an effect central to the phenotype of
familial hyperkalemic hypertension. Although effects on potassium and sodium channels
along the connecting and collecting tubules have also been documented, WNK4 is typically
believed to have little role in modulating sodium chloride reabsorption along the thick
ascending limb of the loop of Henle. Yet wnk4−/− mice (knockout mice lacking WNK4) do not …