Health decision-making for women in South Asia is still perceived and expected to be controlled by family members and male relatives. Even women who work and have independent incomes in the region may relinquish control over autonomous health decision-making in order to be accepted by society and preserve the traditional order. This is why it is important to longitudinally assess patterns of decision-making in South Asian women. In this chapter, we use recent secondary data from the Demographic Health Surveys of Bangladesh, India, and Pakistan to highlight predictors for health decision-making for women of reproductive age. We are able to conclude about salient sociocultural factors which influence or control health decision-making in women of South Asia, including: (i) gender gaps and family factor, (ii) health education and health behavior, (iii) nature of employment, (iv) violence and safety, and (v) quality of healthcare services and traditional healers. We are also able to identify women who are at risk of low decision-making ability for health: (i) younger and older women between the ages of 15 and 49 years, (ii) illiterate and literate women, (iii) rural women, (iv) poor women, (v) women with less than four children, (vi) women who are not working, (vii) women who are not paid in cash, (viii) women who do not watch TV, (ix) women who do not have or have not seen an immunization card of their child, and (x) women who do not believe that beating is justified. We thus recommend ways to improve support for such women, in order to overall improve well-being and quality of life in women.