X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition
Heat shock protein 70 (Hsp70) and Hsp90 are molecular chaperones that play essential
roles in tumor growth by stabilizing pro-survival client proteins. However, although the
development of Hsp90 inhibitors has benefited from the identification of clients, such as Raf-
1 proto-oncogene, Ser/Thr kinase (RAF1), that are particularly dependent on this chaperone,
no equivalent clients for Hsp70 have been reported. Using chemical probes and MDA-MB-
231 breast cancer cells, we found here that the inhibitors of apoptosis proteins, including c …
roles in tumor growth by stabilizing pro-survival client proteins. However, although the
development of Hsp90 inhibitors has benefited from the identification of clients, such as Raf-
1 proto-oncogene, Ser/Thr kinase (RAF1), that are particularly dependent on this chaperone,
no equivalent clients for Hsp70 have been reported. Using chemical probes and MDA-MB-
231 breast cancer cells, we found here that the inhibitors of apoptosis proteins, including c …
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