Xenotransplantation of solid organs in the pig-to-primate model
B Ekser, P Rigotti, B Gridelli, DKC Cooper - Transplant immunology, 2009 - Elsevier
Xenotransplantation using pig organs could solve the significant increasing shortage of
donor organs for allotransplantation. In the last two decades, major progress has been made
in understanding the xenoimmunobiology of pig-to-nonhuman primate transplantation, and
today we are close to clinical trials. The ability to genetically engineer pigs, such as human
decay-accelerating factor (hDAF), CD46 (membrane cofactor protein), or α1, 3-
galactosyltransferase gene-knockout (GT-KO), has been a significant step toward the clinical …
donor organs for allotransplantation. In the last two decades, major progress has been made
in understanding the xenoimmunobiology of pig-to-nonhuman primate transplantation, and
today we are close to clinical trials. The ability to genetically engineer pigs, such as human
decay-accelerating factor (hDAF), CD46 (membrane cofactor protein), or α1, 3-
galactosyltransferase gene-knockout (GT-KO), has been a significant step toward the clinical …
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