Yeast-based assays for screening 11β-HSD1 inhibitors
Background Intracellular metabolism of glucocorticoid hormones plays an important role in
the pathogenesis of metabolic syndrome and regulates, among many physiological
processes, collagen metabolism in skin. At the peripheral level the concentration of active
glucocorticoids is mainly regulated by the 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1)
enzyme, involved in the conversion of cortisone into the biologically active hormone cortisol.
Cortisol interacts with the glucocorticoid receptor and regulates the expression of different …
the pathogenesis of metabolic syndrome and regulates, among many physiological
processes, collagen metabolism in skin. At the peripheral level the concentration of active
glucocorticoids is mainly regulated by the 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1)
enzyme, involved in the conversion of cortisone into the biologically active hormone cortisol.
Cortisol interacts with the glucocorticoid receptor and regulates the expression of different …
Yeast‑based assays for screening 11β‑HSD1 inhibitors
R Vanella, R Callari, A Weston, H Heider, MS Schwab… - 2016 - irf.fhnw.ch
BACKGROUND: Intracellular metabolism of glucocorticoid hormones plays an important role
in the pathogenesis of metabolic syndrome and regulates, among many physiological
processes, collagen metabolism in skin. At the peripheral level the concentration of active
glucocorticoids is mainly regulated by the 11β- hydroxysteroid dehydrogenase 1 (11β-
HSD1) enzyme, involved in the conversion of cortisone into the biologically active hormone
cortisol. Cortisol interacts with the glucocorticoid receptor and regulates the expression of …
in the pathogenesis of metabolic syndrome and regulates, among many physiological
processes, collagen metabolism in skin. At the peripheral level the concentration of active
glucocorticoids is mainly regulated by the 11β- hydroxysteroid dehydrogenase 1 (11β-
HSD1) enzyme, involved in the conversion of cortisone into the biologically active hormone
cortisol. Cortisol interacts with the glucocorticoid receptor and regulates the expression of …
以上显示的是最相近的搜索结果。 查看全部搜索结果