ZAKα/P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome
L Rodríguez‐Ruiz, JM Lozano‐Gil… - EMBO Molecular …, 2023 - embopress.org
Chronic inflammatory diseases are associated with hematopoietic lineage bias, including
neutrophilia and anemia. We have recently identified that the canonical inflammasome
mediates the cleavage of the master erythroid transcription factor GATA1 in hematopoietic
stem and progenitor cells (HSPCs). We report here that genetic inhibition of Nlrp1 resulted in
reduced number of neutrophils and increased erythrocyte counts in zebrafish larvae. We
also found that the NLRP1 inflammasome in human cells was inhibited by LRRFIP1 and …
neutrophilia and anemia. We have recently identified that the canonical inflammasome
mediates the cleavage of the master erythroid transcription factor GATA1 in hematopoietic
stem and progenitor cells (HSPCs). We report here that genetic inhibition of Nlrp1 resulted in
reduced number of neutrophils and increased erythrocyte counts in zebrafish larvae. We
also found that the NLRP1 inflammasome in human cells was inhibited by LRRFIP1 and …
[PDF][PDF] ZAKa/P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome
L Rodrıguez-Ruiz, JM Lozano-Gil, E Naranjo-Sánchez… - 2023 - discovery.dundee.ac.uk
Chronic inflammatory diseases are associated with hematopoietic lineage bias, including
neutrophilia and anemia. We have recently identified that the canonical inflammasome
mediates the cleavage of the master erythroid transcription factor GATA1 in hematopoietic
stem and progenitor cells (HSPCs). We report here that genetic inhibition of Nlrp1 resulted in
reduced number of neutrophils and increased erythrocyte counts in zebrafish larvae. We
also found that the NLRP1 inflammasome in human cells was inhibited by LRRFIP1 and …
neutrophilia and anemia. We have recently identified that the canonical inflammasome
mediates the cleavage of the master erythroid transcription factor GATA1 in hematopoietic
stem and progenitor cells (HSPCs). We report here that genetic inhibition of Nlrp1 resulted in
reduced number of neutrophils and increased erythrocyte counts in zebrafish larvae. We
also found that the NLRP1 inflammasome in human cells was inhibited by LRRFIP1 and …
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