Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells
C Cencioni, F Spallotta, M Savoia, C Kuenne… - Nature …, 2018 - nature.com
Nitric oxide (NO) synthesis is a late event during differentiation of mouse embryonic stem
cells (mESC) and occurs after release from serum and leukemia inhibitory factor (LIF). Here
we show that after release from pluripotency, a subpopulation of mESC, kept in the naive
state by 2i/LIF, expresses endothelial nitric oxide synthase (eNOS) and endogenously
synthesizes NO. This eNOS/NO-positive subpopulation (ESNO+) expresses
mesendodermal markers and is more efficient in the generation of cardiovascular precursors …
cells (mESC) and occurs after release from serum and leukemia inhibitory factor (LIF). Here
we show that after release from pluripotency, a subpopulation of mESC, kept in the naive
state by 2i/LIF, expresses endothelial nitric oxide synthase (eNOS) and endogenously
synthesizes NO. This eNOS/NO-positive subpopulation (ESNO+) expresses
mesendodermal markers and is more efficient in the generation of cardiovascular precursors …
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