Zika virus genomic RNA possesses conserved G-quadruplexes characteristic of the flaviviridae family

AM Fleming, Y Ding, A Alenko… - ACS infectious …, 2016 - ACS Publications
… inspected the Zika viral genome for PQS and found >60 possible sites in the genome capable
of G-… roles, we aligned all Flaviviridae genomes from the NCBI database to identify seven …

Inhibition of Zika virus replication by G-quadruplex-binding ligands

P Majee, A Pattnaik, BR Sahoo, U Shankar… - … Therapy-Nucleic Acids, 2021 - cell.com
Zika virus (ZIKV), a mosquito-transmitted Flavivirus, emerged in … In this study, we identified
several novel conserved potential … Yellow fever virus (YFV), belongs to the Flaviviridae family. …

Colocalization of m6A and G-Quadruplex-Forming Sequences in Viral RNA (HIV, Zika, Hepatitis B, and SV40) Suggests Topological Control of Adenosine N6 …

AM Fleming, NLB Nguyen, CJ Burrows - ACS central science, 2019 - ACS Publications
… Studies have demonstrated that PQSs are highly conserved and can fold to G-quadruplexes
, and Zika viruses identified conserved regions of m 6 A installation across the flaviviruses

Structure of an RNA G-quadruplex from the West Nile virus genome

JR Terrell, TT Le, A Paul, MA Brinton… - Nature …, 2024 - nature.com
… are conserved across members of this genus. Subsequent biophysical studies established
that some G-quadruplexes predicted in Zika … (WNV), yellow fever virus and Zika virus (ZIKV), …

Guanine quadruplexes in the RNA genome of the tick-borne encephalitis virus: their role as a new antiviral target and in virus biology

J Holoubek, K Bednářová, J Haviernik… - Nucleic Acids …, 2022 - academic.oup.com
RNA genome of the Zika virus (ZIKV) and other members of the genus Flavivirus contain
conserved RNA … The TBEV, as a typical flavivirus, is a small (∼50 nm in diameter), enveloped, …

Role of RNA G-Quadruplexes in the Japanese Encephalitis Virus Genome and Their Recognition as Prospective Antiviral Targets

A Singh, P Majee, L Mishra, SK Prajapat… - ACS Infectious …, 2024 - ACS Publications
… (13) The Zika virus, a member of the Flaviviridae family, has … structural characteristics of RNA
G-quadruplexes in the JEV genome, … conserved putative G-quadruplexes (PGQs) in the JEV …

Identification and characterization of two conserved G-quadruplex forming motifs in the Nipah virus genome and their interaction with G-quadruplex specific ligands

P Majee, S Kumar Mishra, N Pandya, U Shankar… - Scientific reports, 2020 - nature.com
… A recent review on G-quadruplexes in viruses and ligands … Genome-wide screening in Human
Papillomavirus, Zika virus… , PDS, etc. possess a characteristic planar aromatic surface. The …

Conserved Sequences from Dengue Virus Genomes Form Stable G-Quadruplexes

JL Siemer, TT Le, A Paul, DW Boykin… - ACS Infectious …, 2024 - ACS Publications
Zika Virus Genomic RNA Possesses Conserved G-Quadruplexes Characteristic of the
Flaviviridae Family. … Inhibition of Zika virus replication by G-quadruplex-binding ligands. Mol. Ther …

G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide

E Lavezzo, M Berselli, I Frasson… - PLoS computational …, 2018 - journals.plos.org
… PQSs are features characteristic of each virus class and family. Our … viral genomes can be
highly variable, G-quadruplexes with important functional roles are expected to be conserved

G-quadruplexes in the viral genome: unlocking targets for therapeutic interventions and antiviral strategies

R Pathak - Viruses, 2023 - mdpi.com
… The typical sequence forming G-quadruplexes is generally … The Zika virus belongs to the
Flavivirus genus within the … found to be conserved across 66 viral genomes from the Flaviviridae