Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage
Zika virus (ZIKV) infection of pregnant women can result in fetal brain abnormalities. It has
been established that ZIKV disrupts neural progenitor cells (NPCs) and leads to embryonic
microcephaly. However, the fate of other cell types in the developing brain and their
contributions to ZIKV-associated brain abnormalities remain largely unknown. Using
intracerebral inoculation of embryonic mouse brains, we found that ZIKV infection leads to
postnatal growth restriction including microcephaly. In addition to cell cycle arrest and …
been established that ZIKV disrupts neural progenitor cells (NPCs) and leads to embryonic
microcephaly. However, the fate of other cell types in the developing brain and their
contributions to ZIKV-associated brain abnormalities remain largely unknown. Using
intracerebral inoculation of embryonic mouse brains, we found that ZIKV infection leads to
postnatal growth restriction including microcephaly. In addition to cell cycle arrest and …
Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage.
SQ Shao Qiang, S Herrlinger, YSL Yang SiLu… - 2016 - cabidigitallibrary.org
Zika virus (ZIKV) infection of pregnant women can result in fetal brain abnormalities. It has
been established that ZIKV disrupts neural progenitor cells (NPCs) and leads to embryonic
microcephaly. However, the fate of other cell types in the developing brain and their
contributions to ZIKV-associated brain abnormalities remain largely unknown. Using
intracerebral inoculation of embryonic mouse brains, we found that ZIKV infection leads to
postnatal growth restriction including microcephaly. In addition to cell cycle arrest and …
been established that ZIKV disrupts neural progenitor cells (NPCs) and leads to embryonic
microcephaly. However, the fate of other cell types in the developing brain and their
contributions to ZIKV-associated brain abnormalities remain largely unknown. Using
intracerebral inoculation of embryonic mouse brains, we found that ZIKV infection leads to
postnatal growth restriction including microcephaly. In addition to cell cycle arrest and …
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