Artificial intelligence (AI) refers to computer capabilities that resemble human intelligence. AI implies the ability to learn and perform tasks that have not been specifically programmed. Moreover, it is an iterative process involving the ability of computerized systems to capture information, transform it into knowledge, and process it to produce adaptive changes in the environment. A large labeled database is needed to train the AI system and generate a robust algorithm. Otherwise, the algorithm cannot be applied in a generalized way. AI can facilitate the interpretation and acquisition of radiological images. In addition, it can facilitate the detection of trauma injuries and assist in orthopedic and rehabilitative processes. The applications of AI in musculoskeletal conditions are promising and are likely to have a significant impact on the future management of these patients.