Functional landscape of SARS-CoV-2 cellular restriction

L Martin-Sancho, MK Lewinski, L Pache, CA Stoneham… - Molecular cell, 2021 - cell.com
… IFN-mediated restriction of SARS-CoV-2 relies on a limited subset of ISGs To define the
cellular effectors that act to limit SARS-CoV-2 infection, we first sought to determine which genes …

The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2

RD Chow, M Majety, S Chen - Nature Communications, 2021 - nature.com
coronavirus disease-2019 (COVID-19). Here, we interrogate the transcriptional features and
cellular landscape … associated changes with experimental data on SARS-CoV-2, we identify …

Mutational landscape and interaction of SARS-CoV-2 with host cellular components

M Srivastava, D Hall, OB Omoru, HM Gill, S Smith… - Microorganisms, 2021 - mdpi.com
cellular components targeted by the virus during SARS-CoV-2 infection. We also summarize
the mutations across the SARS-CoV… and their impact on host cellular machinery. Finally, we …

[HTML][HTML] The spatio-temporal landscape of lung pathology in SARS-CoV-2 infection

AF Rendeiro, H Ravichandran, Y Bram, J Kim… - Nature, 2021 - ncbi.nlm.nih.gov
… We provide evidence that SARS-CoV-2 infects predominantly alveolar epithelial cells and …
landscape. This confers biological interpretability to the landscape, as the underlying cellular

Single-cell analysis of adult human heart across healthy and cardiovascular disease patients reveals the cellular landscape underlying SARS-CoV-2 invasion of …

C Chen, J Wang, YM Liu, J Hu - Journal of Translational Medicine, 2023 - Springer
… binding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are crucial to …
We used co-expression analysis to locate specific cell types that SARS-CoV-2 may invade. …

SARS-CoV-2 achieves immune escape by destroying mitochondrial quality: comprehensive analysis of the cellular landscapes of lung and blood specimens from …

C Duan, R Ma, X Zeng, B Chen, D Hou, R Liu… - Frontiers in …, 2022 - frontiersin.org
… mitochondria into the cellular environment (14). Recent research has shown that SARS-CoV-2 …
comprise one of the first lines of defense against SARS-CoV-2 infection (15). Compared …

Multiomics: unraveling the panoramic landscapes of SARS-CoV-2 infection

X Wang, G Xu, X Liu, Y Liu, S Zhang… - Cellular & Molecular …, 2021 - nature.com
coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV… at both the molecular and cellular levels. The recent development of …

[HTML][HTML] The translational landscape of SARS-CoV-2 and infected cells

M Puray-Chavez, N Lee, K Tenneti, Y Wang, HR Vuong… - bioRxiv, 2020 - ncbi.nlm.nih.gov
… We find that SARS-CoV-2 mRNAs dominate the cellular mRNA pool but are not more
efficiently translated than cellular mRNAs. SARS-CoV-2 utilized a highly efficient ribosomal …

SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic

A Bertoletti, N Le Bert, AT Tan - Immunity, 2022 - cell.com
… multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with …
cellular immunity. In this review, we summarized the evidence that supports the role of SARS-CoV-…

The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA-supertype-dependent manner

DJ Hamelin, D Fournelle, JC Grenier, J Schockaert… - Cell systems, 2022 - cell.com
SARS-CoV-2 has led to the emergence of a diverse range of variants. Here, we describe how
the mutational landscape of SARS-CoV… total of 330,246 high-quality SARS-CoV-2 genome …