cis-[RuCl (BzCN)(bipy)(dppe)] PF6 induces anti-angiogenesis and apoptosis by a mechanism of caspase-dependent involving DNA damage, PARP activation, and …
LF Magalhaes, F Mello-Andrade, WC Pires… - Chemico-Biological …, 2017 - Elsevier
Antimetastatic activities, low toxicity to normal cells and high selectivity for tumor cells make
of the ruthenium complexes promising candidates in the search for develop new
chemotherapeutic agents for the treatment of cancer. This study aimed to determine the
cytotoxic, genotoxic and to elucidate the signaling pathway involved in the death cell
process induced by cis-[RuCl (BzCN)(bipy)(dppb)] PF 6 (1) and cis-[RuCl
(BzCN)(bipy)(dppe)] PF 6 (2) in Ehrlich ascites carcinoma (EAC) in vitro. Moreover, we …
of the ruthenium complexes promising candidates in the search for develop new
chemotherapeutic agents for the treatment of cancer. This study aimed to determine the
cytotoxic, genotoxic and to elucidate the signaling pathway involved in the death cell
process induced by cis-[RuCl (BzCN)(bipy)(dppb)] PF 6 (1) and cis-[RuCl
(BzCN)(bipy)(dppe)] PF 6 (2) in Ehrlich ascites carcinoma (EAC) in vitro. Moreover, we …