Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer

J Frigola, X Solé, MF Paz, V Moreno… - Human molecular …, 2005 - academic.oup.com
… Therefore, the roles of cumulated hypermethylation and hypomethylation in colorectal cancer
… information on the methylation status of more than 200 selected sequences in a series of …

Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study

M Pufulete, R Al-Ghnaniem, AJM Leather, P Appleby… - Gastroenterology, 2003 - Elsevier
… Low folate intake may increase risk for colorectal cancer by inducing DNA hypomethylation.
This study reports the influence of folate status, DNA methylation, and polymorphisms of …

[HTML][HTML] LINE-1 hypomethylation status of circulating cell-free DNA in plasma as a biomarker for colorectal cancer

Y Nagai, E Sunami, Y Yamamoto, K Hata, S Okada… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is a serious public health problem and non-invasive biomarkers …
-1) hypomethylation as a blood biomarker for CRC. LINE-1 hypomethylation level in plasma …

Evaluation of global and intragenic hypomethylation in colorectal adenomas improves patient stratification and colorectal cancer risk prediction

C Debernardi, L Libera, E Berrino, N Sahnane… - Clinical …, 2021 - Springer
hypomethylation has been associated with colorectal cancer … mucosa to adenomas, the
colorectal precancerous lesions [17]. … In this study, DNA hypomethylation status was independent …

Tumor LINE-1 methylation level and microsatellite instability in relation to colorectal cancer prognosis

K Inamura, M Yamauchi, R Nishihara… - … the National Cancer …, 2014 - academic.oup.com
… -1 hypomethylation status in strata of MSI status. A Cox proportional hazards model was
used to compute multivariable CRC-specific mortality hazard ratios (HRs) for a 10% decrease in …

Three DNA methylation epigenotypes in human colorectal cancer

K Yagi, K Akagi, H Hayashi, G Nagae, S Tsuji… - Clinical Cancer …, 2010 - AACR
… To compare the three colorectal cancer epigenotypes with classical CIMP status, we decided
the classical CIMP status of 149 colorectal cancer samples using 11 CIMP-related markers (…

Methylation-based therapies for colorectal cancer

K Cervena, A Siskova, T Buchler, P Vodicka… - Cells, 2020 - mdpi.com
status for their predictive value. This review also includes the therapy outcomes based on the
patient’s methylation status in … DNA hypomethylation has been observed during low folate …

The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer

K Matsuzaki, G Deng, H Tanaka, S Kakar, S Miura… - Clinical cancer …, 2005 - AACR
… In conclusion, our study shows that the global hypomethylation status of colorectal tumors
correlates with LOH. These results, together with recent studies by other investigators (12–16), …

Genome-scale analysis of DNA methylation in colorectal cancer using Infinium HumanMethylation450 BeadChips

VA Naumov, EV Generozov, NB Zaharjevskaya… - Epigenetics, 2013 - Taylor & Francis
… that hybridized to the gene body region showed hypomethylated statuses. Of the 3,152 total
DM genes identified using the site-level test, 444 show both types of methylation differences. …

MUC5AC hypomethylation is a predictor of microsatellite instability independently of clinical factors associated with colorectal cancer

F Renaud, A Vincent, C Mariette… - … journal of cancer, 2015 - Wiley Online Library
MUC5AC hypomethylation is a predictor of microsatellite instability independently of clinical
factors associated with colorectal cancer - Renaud - 2015 - International Journal of Cancer - …