IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome

S Kang, T Tanaka, H Inoue, C Ono… - Proceedings of the …, 2020 - National Acad Sciences
… Consistent with previous reports, the serum IL-6 concentrations in the severe COVID-19
patients examined in this study were relatively lower than those in patients with severe ARDS (29…

COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue

X Yongzhi - Emerging microbes & infections, 2021 - Taylor & Francis
… (MAS), infection-associated hemophagocytic syndrome, cytokine release syndrome (CRS),
and cytokine storm (CS). Hematologic malignancies and autoimmune diseases that cause …

[HTML][HTML] Tocilizumab in a child with acute lymphoblastic leukaemia and COVID-19-related cytokine release syndrome

PV Puyó, L Moreno, CD de Heredia, JG Rivière… - Anales de …, 2020 - ncbi.nlm.nih.gov
… Due to suspicion of cytokine release syndrome (CRS), described elsewhere as a predictor …
levels of C-reactive protein (CRP), interleukin-6 (IL-6) and ferritin (Fig. 1 ), and the patient was …

[HTML][HTML] Laboratory parameters predicting mortality of adult in-patients with COVID-19 associated cytokine release syndrome treated with high-dose tocilizumab

B Lakatos, BG Szabo, I Bobek, L Gopcsa… - Acta Microbiologica et …, 2021 - akjournals.com
… tocilizumab for critically ill COVID-19 patients requiring organ … IL-6 blockade with tocilizumab
may be demonstrated in the presence of COVID-19 associated cytokine release syndrome

[HTML][HTML] HIV and Associated indicators of COVID-19 cytokine release syndrome: a Meta-analysis and Meta-regression

JK Muthuka Jr, K Oluoch, FM Wambura, JM Nzioki… - Cureus, 2023 - ncbi.nlm.nih.gov
… The aim of this review was to evaluate the risk of COVID-19 cytokine release syndrome (CRS)
with HIV infection and meta-regress for indicator covariates. Electronic databases, …

[HTML][HTML] The effectiveness of continuous renal replacement therapy in critical COVID-19 patients with cytokine release syndrome: a retrospective, multicenter …

H Xiang, B Song, Y Zhang, J Zhang, J Xiong - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
… such as multiple organ disease syndrome related to cytokine release syndrome (CRS). …
cytokines through filtration or adsorption. We evaluated the effectiveness of CRRT in COVID-19

Spotlight on tocilizumab in the treatment of CAR-T-cell-induced cytokine release syndrome: clinical evidence to date

S Si, DT Teachey - Therapeutics and clinical risk management, 2020 - Taylor & Francis
… The current coronavirus disease 2019 (COVID-19) pandemic has inflicted a devastatingly
high morbidity and mortality rate across the globe. Citation69,Citation70 Although we are only …

Tocilizumab treatment for cytokine release syndrome in hospitalized patients with coronavirus disease 2019.

CC Price, FL Altice, Y Shyr, A Koff, L Pischel, G Goshua… - 2020 - cabidigitallibrary.org
release syndrome (CRS), with observed improvements in a coronavirus disease 2019 (COVID-19) …
with COVID-19. Study Design and Methods: This observational study of consecutive …

Interleukin-1 Receptor Antagonist Gene (IL1RN) Variants Modulate the Cytokine Release Syndrome and Mortality of COVID-19

M Attur, C Petrilli, S Adhikari, E Iturrate… - The Journal of …, 2024 - academic.oup.com
cytokine release syndrome (CRS) and mortality in patients with acute severe respiratory
syndrome coronavirus 2 (… the severity of coronavirus disease 2019 (COVID-19) via endogenous …

[HTML][HTML] How COVID-19 induces cytokine storm with high mortality

S Hojyo, M Uchida, K Tanaka, R Hasebe… - Inflammation and …, 2020 - Springer
… fatal COVID-19 is characterized as a cytokine release syndrome (CRS) that is induced by a
… of COVID-19, we propose that IL-6 plays a pivotal role in the disease augmentation and can …