Weathering the cytokine storm in COVID-19: therapeutic implications

G Iannaccone, R Scacciavillani, MG Del Buono… - Cardiorenal …, 2020 - karger.com
cytokine release in response to viral infection, a condition known as cytokine release syndrome
(CRS) or cytokine … to ARDS and MOF in COVID-19, thus endorsing the hypothesis that …

[HTML][HTML] Effectiveness of tocilizumab in a COVID-19 patient with cytokine release syndrome

S Uslu - European journal of case reports in internal medicine, 2020 - ncbi.nlm.nih.gov
… We describe a case of CRS caused by severe COVID-19 infection with a favourable … -6
(IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (…

Galectin-9, a player in cytokine release syndrome and a surrogate diagnostic biomarker in SARS-CoV-2 infection

N Bozorgmehr, S Mashhouri, E Perez Rosero, L Xu… - MBio, 2021 - Am Soc Microbiol
… cells of COVID-19 patients once treated with Gal-9 in vitro. Our results propose Gal-9 as an
important contributing factor in cytokine release syndrome; … activation in COVID-19 patients. …

Interleukin-6 antagonists: Lessons from cytokine release syndrome to the therapeutic application in severe COVID-19 infection

J Meanwatthana, T Majam - Journal of Pharmacy Practice, 2022 - journals.sagepub.com
… after initiating IL-6 antagonists. In summary, IL-6 pathway inhibition in severe COVID-19 may
… These agents may carry benefits in COVID-19 infection as well as safety risks such as bone …

Cytokines and COVID-19: friends or foes?

M Rokni, MR Hamblin, N Rezaei - Human vaccines & …, 2020 - Taylor & Francis
… In conclusion, the cytokine release syndrome occurs in a majority of patients with severe
COVID-19, which is also an … IL-6 and JAK are the key molecules involved in the cytokine

Capturing cytokines with advanced materials: a potential strategy to tackle COVID19 cytokine storm

QF Meng, R Tian, H Long, X Wu, J Lai… - Advanced …, 2021 - Wiley Online Library
… by severe acute respiratory syndrome coronavirus 2 (SARS-… In the clinic, most patients
with COVID-19 show none or mild … -induced cytokine release syndrome (the so-called “cytokine

Cytokine storm in COVID-19: immunopathogenesis and therapy

C Zanza, T Romenskaya, AC Manetti, F Franceschi… - Medicina, 2022 - mdpi.com
… This drug has been used successfully in numerous autoimmune and auto-inflammatory
conditions, including cytokine release syndrome (CRS) secondary to CAR-T cell therapy and …

The cytokine storm and COVID19

B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
… understanding of the cytokine storm in severe COVID-19. Therefore… strategies for the cytokine
storm in severe COVID-19. … 1, and cytokine secretion patterns based on COVID-19 severity …

[HTML][HTML] Cytokine “storm”, cytokine “breeze”, or both in COVID-19?

G Lippi, M Plebani - Clinical Chemistry and Laboratory Medicine …, 2021 - degruyter.com
… In a cohort of 299 COVID-19 patients, a cHIS score ≥2 was associated with 92… a cytokine
“storm” in COVID-19. Although it is unquestionable that the values of proinflammatory cytokines

Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome

LYC Chen, RL Hoiland, S Stukas… - European …, 2020 - Eur Respiratory Soc
release syndrome (CAR T-cell CRS) became apparent [3–5]. The … cytokines, in severe
COVID-19, peripheral blood mononuclear cells exhibit sustained TNF-α and IL-6 production with …