Severe COVID-19: immunosuppression or hyperinflammation?

Y Liu, Y Li, D Xu, J Zhang, Z Peng - Shock, 2021 - journals.lww.com
… of COVID-19 and causes a delay in recovery. Additionally, the relevant immunopathological
mechanisms … , and effective immunological treatments for COVID-19 are still being explored. …

Targeting arginine in COVID-19-induced immunopathology and vasculopathy

W Durante - Metabolites, 2022 - mdpi.com
… is degraded in patients with COVID-19, providing a structural mechanism that limits NO
production in response to flow [125,126]. Furthermore, the loss of the endothelial glycocalyx in …

[HTML][HTML] The potential role of Th17 immune responses in coronavirus immunopathology and vaccine-induced immune enhancement

PJ Hotez, ME Bottazzi, DB Corry - Microbes and infection, 2020 - Elsevier
… Additional research may also clarify links between COVID-19 pulmonary immunopathology
… the underlying mechanisms of eosinophilic immunopathology associated with coronavirus

Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology

CMS Silva, CWS Wanderley, FP Veras, AV Gonçalves… - Critical Care, 2022 - Springer
COVID-19. However, the molecular mechanisms underlying the release of NETs in COVID-19
… of GSDMD-dependent NETosis to COVID-19 immunopathology, we infected K18 hACE2 …

Immunological mechanisms of vaccine-induced protection against COVID-19 in humans

M Sadarangani, A Marchant… - Nature Reviews …, 2021 - nature.com
… To accurately identify a correlate and/or mechanism of protection against COVID-19, trial …
innate immune mechanisms. Reduced protection against any symptomatic COVID-19 disease …

Post-mortem lung tissue: the fossil record of the pathophysiology and immunopathology of severe COVID-19

L Milross, J Majo, N Cooper, PM Kaye… - The Lancet …, 2022 - thelancet.com
… be driven by immunopathology. However, superimposed infection and thrombotic complications
also precipitate clinical deterioration. The precise pathophysiological mechanisms that …

Immune complexes as culprits of immunopathology in severe COVID-19

P Kolb, S Giese, RE Voll, H Hengel… - Medical Microbiology and …, 2023 - Springer
… While clinical evidence for molecular mimicry is still missing, the latter mechanism has
been frequently described in COVID-19. Amongst others, an unexpectedly high percentage of …

COVID-19 and multiorgan failure: A narrative review on potential mechanisms

T Mokhtari, F Hassani, N Ghaffari, B Ebrahimi… - Journal of molecular …, 2020 - Springer
… While the common cold symptoms are observed in mild cases, COVID-19COVID-19
patients, particularly in severe cases. Also, we tried to define the potential underlying mechanisms

COVID-19, immune system response, hyperinflammation and repurposingantirheumatic drugs

A Tufan, AA Güler… - Turkish journal of medical …, 2020 - journals.tubitak.gov.tr
… Eventually, the exact pathophysiologic mechanism of COVID-19 remains still largely … in
COVID-19 patients [80]. Blockage of this growth factor may halt immunopathology caused by virus…

Animal models of mechanisms of SARS‐CoV‐2 infection and COVID19 pathology

SJ Cleary, SC Pitchford, RT Amison… - British journal of …, 2020 - Wiley Online Library
… key mechanisms of COVID-19 severe acute respiratory distress syndrome and the
immunopathology … -CoV-2 infection and COVID-19-related disease mechanisms and suggest …