… Thus, the impairment in antiviral resistance and unregulated inflammasome activation
may underlie the perfect storm for the severe disease we observe in the COVID-19 patients. …

… indirect inflammasome activation and the critical role of inflammasomes in severe COVID-19. …
Nonetheless, overactivation of inflammasome signalling and pyroptosis are increasingly …

… Pyroptotic T-cell depletion in patients with COVID-19 may not … critical role of the inflammasome
in COVID-19 have therapeutic … prevention of pyroptosis in COVID-19 may be beneficial. …

… clinical symptoms in COVID-19, we aimed to suggest the possible role of NLRP3 inflammasome
as a … cell pyroptosis in COVID-19 may be linked to obesity. In individuals with obesity, …

… Morphological analysis of sorted mNG + cells revealed the appearance of membrane
bubbles—a characteristic of pyroptosis—prompting us to investigate inflammasome activation as …

… by coronavirus infection and that impaired NLRP3 inflammasome function or pyroptosis can
… These findings may have important implications for studies of coronavirus-induced disease. …

… Thus, SARS-CoV-2/COVID-19 may directly impair the viability and proliferative potential of
… inflammasome leading to pyroptosis. On the other hand, activation of Nlrp3 inflammasome in …

… ASC, and ORF8b interacts with NLRP3, resulting in inflammasome activation and pyroptosis.
IL-1β is released through the GSDM-DN pore during pyroptosis, while Na + and H 2 O …

… is one of the most important innate immune components, which facilitates inflammation by
producing IL-1β/18 and causing pyroptosis. With the development of the inflammatory cascade…

… inflammasome-mediated pyroptosis as one of the key mechanisms involved in COVID-19
(… Consequently, a further exacerbation of symptoms may derive from the pyroptosis-induced …