Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions

Y Jamilloux, T Henry, A Belot, S Viel, M Fauter… - Autoimmunity …, 2020 - Elsevier
… This leads to an influx of neutrophils and monocytes-macrophages (the major sources of
pro-inflammatory cytokines) and further apoptosis of T cells, epithelial and endothelial cells [[52]…

Cytokines and their relationship with the severity and prognosis of coronavirus disease 2019 (COVID-19): a retrospective cohort study

QQ Liu, A Cheng, Y Wang, H Li, L Hu, X Zhao… - BMJ open, 2020 - bmjopen.bmj.com
COVID-19 severity and in-hospital mortality. Thus, our study indicates that cytokines are
valuable in predicting the severity of COVID-19 … . Induction of pro-inflammatory cytokines (IL-1 …

Inflammatory Markers and Cytokines in Moderate and Critical Cases of COVID-19.

SH Chang, D Minn, SW Kim, YK Kim - Clinical Laboratory, 2021 - search.ebscohost.com
… storm is a systemic inflammatory response that can be caused by infection as well as
other factors and is characterized by a sharp increase of various proinflammatory cytokines [7,8]. …

COVID-19 revisiting inflammatory pathways of arthritis

G Schett, B Manger, D Simon, R Caporali - Nature Reviews …, 2020 - nature.com
… by severe acute respiratory syndrome coronavirus 2, which predominantly … and cytokine
response in alveolar structures. The pattern of pro-inflammatory cytokines induced in COVID-19

COVID-19: immunopathology and its implications for therapy

X Cao - Nature reviews immunology, 2020 - nature.com
… severe COVID-19 exhibit substantially elevated serum levels of pro-inflammatory cytokines
… , MIP1α (also known as CCL3) and TNF, characterized as cytokine storm 1,2,3,4 . Also, C-…

Clinical significance of measuring serum cytokine levels as inflammatory biomarkers in adult and pediatric COVID-19 cases: A review

BM Liu, TB Martins, LK Peterson, HR Hill - Cytokine, 2021 - Elsevier
… Measuring serum levels of pro-inflammatory cytokines may have several potential
applications in the management of COVID-19, including risk assessment, monitoring of disease …

NF-κB pathway as a potential target for treatment of critical stage COVID-19 patients

R Kircheis, E Haasbach, D Lueftenegger… - Frontiers in …, 2020 - frontiersin.org
pro-inflammatory signal pathway, NF-κB, in the context of recently published data for COVID-19
… of pro-inflammatory cytokines and chemokines. The simultaneous inhibition of multiple …

Complement anaphylatoxins and inflammatory cytokines as prognostic markers for COVID-19 severity and in-hospital mortality

B Alosaimi, A Mubarak, ME Hamed… - Frontiers in …, 2021 - frontiersin.org
… complement system and higher levels of pro-inflammatory cytokines/chemokines in critical
COVID-19 patients were significantly correlated with critical COVID-19 in-hospital mortality. …

Cytokine storm in COVID-19: immunopathogenesis and therapy

C Zanza, T Romenskaya, AC Manetti, F Franceschi… - Medicina, 2022 - mdpi.com
… Moreover, cytokine storm has recently emerged as a key aspect in the novel Coronavirus
disease 2019, as affected patients show high levels of several key pro-inflammatory cytokines, …

Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects

R Dharra, AK Sharma, S Datta - Cytokine, 2023 - Elsevier
… This results in the production of extensive levels of pro-inflammatory cytokine/s (… COVID-19-associated
CS patients display elevated levels of several critical proinflammatory cytokines, …