Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis

ZA Rizvi, P Babele, S Sadhu, U Madan… - Frontiers in …, 2022 - frontiersin.org
… , we found that GG remarkably inhibited pro-inflammatory cytokines in a way that was
comparable to remdesivir, a prototype of antiviral drug. Higher levels of cytokines such as TNFα …

[HTML][HTML] Cytokine storm intervention in the early stages of COVID-19 pneumonia

X Sun, T Wang, D Cai, Z Hu, H Liao, L Zhi, H Wei… - Cytokine & growth factor …, 2020 - Elsevier
… Targeted S1P1 antagonism inhibited the recruitment of inflammatory cells, limited pro-inflammatory
cytokine/chemokine release, and reduced mortality and morbidity induced by …

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

GH Meftahi, Z Jangravi, H Sahraei, Z Bahari - Inflammation Research, 2020 - Springer
… release, which is described as cytokine storm, is a pivotal pathophysiological … in elderly
COVID-19 patients [4]. Aging is related to increased levels of systemic pro-inflammatory cytokines

Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors

H Han, Q Ma, C Li, R Liu, L Zhao, W Wang… - Emerging microbes & …, 2020 - Taylor & Francis
… IL-6 acts as a major pro-inflammatory mediator for the induction of the acute phase
response [Citation22], leading to a wide range of local and systemic changes including fever, …

Tackling the COVID-19 cytokine storm” with microRNA mimics directly targeting the 3'UTR of pro-inflammatory mRNAs

J Gasparello, A Finotti, R Gambari - Medical Hypotheses, 2021 - Elsevier
COVID-19 is characterized … “cytokine storm”, caused by activation of pro-inflammatory genes,
such as NF-kB, STAT-3, IL-6, IL-8, G-CSF [2], [3], [4], [5], [6], [7], [8], [9]. In COVID-19 cytokine

COVID-19: inflammatory profile

Y Wang, S Perlman - Annual review of medicine, 2022 - annualreviews.org
… Further understanding and definition of cytokines and chemokines involved in COVID-19-…
Here, we discuss the key cytokines and chemokines involved in COVID-19 pathogenesis. …

Analysis of differential gene expression of pro-inflammatory cytokines in the nasopharyngeal milieu of mild & severe COVID-19 cases

U Ghulam, F Nazim, N Farooqui, S Rizwan-ul-Hasan… - Plos one, 2022 - journals.plos.org
COVID-19 disease and many pro-inflammatory cytokines are … activity of the anti-viral cytokines
ensures viral clearance [25, … of cytokines in the mild and severe COVID-19 patient groups …

Mechanism of inflammatory response in associated comorbidities in COVID-19

TMC de Lucena, AF da Silva Santos… - Diabetes & Metabolic …, 2020 - Elsevier
… conditions and affected by COVID-19 present an uncontrolled release of pro-inflammatory
cytokines and an unbalanced immune response, leading to the cytokine storm phenomenon. …

Pro-and anti-inflammatory responses in severe COVID-19-induced acute respiratory distress syndrome—an observational pilot study

Q Notz, M Schmalzing, F Wedekink… - Frontiers in …, 2020 - frontiersin.org
… Innate antiviral immune sensing via types I and III IFN leads to the production of pro-inflammatory
cytokines (ie IL-6) within the first week after virus infection. IL-6 activates and …

Cytokine prediction of mortality in COVID19 patients

M Mandel, G Harari, M Gurevich, A Achiron - Cytokine, 2020 - Elsevier
Coronavirus disease 2019 (COVID19) is a life-threatening infection with uncertain …
hospitalized patients diagnosed with COVID19. Pro-inflammatory cytokines were assessed during …