High-throughput viability screens are commonly used in the identification and development
of chemotherapeutic drugs. These systems rely on the fidelity of the cellular model systems
to recapitulate the drug response that occurs in vivo. In recent years, there has been an
expansion in the utilization of patient-derived materials as well as advanced cell culture
techniques, such as multi-cellular tumor organoids, to further enhance the translational
relevance of cellular model systems. Simple quantitative analysis remains a challenge …