… , including pathological changes in brains. This review mainly … of SARS-CoV-2 invading humanbrain and the molecular basis of SARS-CoV-2 infection interfering with humanbrain and …
D Chertow, S Stein, S Ramelli, A Grazioli, JY Chung… - 2021 - academia.edu
… -2 cellular 260 tropism, quantification, and persistence across the body and brain, in a diverse … We show SARS-CoV-2 disseminates across the human body and brain early in infection …
… observed after SARS-CoV-2 infection could be (1) directly caused by the virus infecting brain cells, … As indisputable evidence of intact and replicating SARS-CoV-2 particles in the central …
… Here, we use human-pluripotent-stem-cell-derived brain organoids to examine SARS-CoV-2 … We challenge organoids with SARS-CoV-2 spike pseudovirus and live virus to demonstrate …
A Ramani, L Müller, PN Ostermann, E Gabriel… - The EMBO …, 2020 - embopress.org
… SARS-CoV-2 readily targets neurons of 3D humanbrain organoids. Neurons invaded with SARS-CoV-… show that although SARS-CoV-2 can readily target brain organoids, SARS-CoV-2 …
WJ Lukiw, A Pogue, JM Hill - Cellular and molecular neurobiology, 2022 - Springer
… of the mechanism and pathways of SARS-CoV-2 infection and … SARS-CoV-2 attack in this communication we analyzed ACE2 expression in 85 human tissues including 21 different brain …
A Ramani, AI Pranty, J Gopalakrishnan - Stem cell reports, 2021 - cell.com
… neurotropic effects of SARS-CoV-2. Here, we summarize the neurotoxic effects of SARS-CoV-2 using brain organoids and comprehensively discuss how brain organoids could further …
… whether SARS-CoV-2 could infect 3D humanbrain organoids. We generated iPSC-derived humanbrain organoids using previously described protocols. The 35-day-old brain …
… mice, and infections of humanbrain organoids: that SARS-CoV-2 … , and the disruption of brain vasculature can make vulnerable … of humanbrain organoids, beyond modeling fetal brains, …