[HTML][HTML] SARS-CoV-2 productively infects human brain microvascular endothelial cells

RC Yang, K Huang, HP Zhang, L Li, YF Zhang… - Journal of …, 2022 - Springer
… of the vascular endothelium in brain. Moreover, we demonstrated that SARS-CoV-2 infection
could … Our findings demonstrated that SARS-CoV-2 infection can cause BBB dysfunction, …

[HTML][HTML] Long-term effects of SARS-CoV-2 infection on human brain and memory

Q Ding, HJ Zhao - Cell Death Discovery, 2023 - nature.com
… , including pathological changes in brains. This review mainly … of SARS-CoV-2 invading
human brain and the molecular basis of SARS-CoV-2 infection interfering with human brain and …

[PDF][PDF] SARS-CoV-2 infection and persistence throughout the human body and brain

D Chertow, S Stein, S Ramelli, A Grazioli, JY Chung… - 2021 - academia.edu
… -2 cellular 260 tropism, quantification, and persistence across the body and brain, in a diverse
… We show SARS-CoV-2 disseminates across the human body and brain early in infection …

[HTML][HTML] What SARS-CoV-2 does to our brains

T Aschman, R Mothes, FL Heppner, H Radbruch - Immunity, 2022 - cell.com
… observed after SARS-CoV-2 infection could be (1) directly caused by the virus infecting brain
cells, … As indisputable evidence of intact and replicating SARS-CoV-2 particles in the central …

[HTML][HTML] SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF barrier in human brain organoids

L Pellegrini, A Albecka, DL Mallery, MJ Kellner, D Paul… - Cell stem cell, 2020 - cell.com
… Here, we use human-pluripotent-stem-cell-derived brain organoids to examine SARS-CoV-2 …
We challenge organoids with SARS-CoV-2 spike pseudovirus and live virus to demonstrate …

SARSCoV‐2 targets neurons of 3D human brain organoids

A Ramani, L Müller, PN Ostermann, E Gabriel… - The EMBO …, 2020 - embopress.org
SARS-CoV-2 readily targets neurons of 3D human brain organoids. Neurons invaded with
SARS-CoV-… show that although SARS-CoV-2 can readily target brain organoids, SARS-CoV-2 …

[HTML][HTML] SARS-CoV-2 infectivity and neurological targets in the brain

WJ Lukiw, A Pogue, JM Hill - Cellular and molecular neurobiology, 2022 - Springer
… of the mechanism and pathways of SARS-CoV-2 infection and … SARS-CoV-2 attack in this
communication we analyzed ACE2 expression in 85 human tissues including 21 different brain

[HTML][HTML] Neurotropic effects of SARS-CoV-2 modeled by the human brain organoids

A Ramani, AI Pranty, J Gopalakrishnan - Stem cell reports, 2021 - cell.com
… neurotropic effects of SARS-CoV-2. Here, we summarize the neurotoxic effects of SARS-CoV-2
using brain organoids and comprehensively discuss how brain organoids could further …

[HTML][HTML] SARS-CoV-2 infects human neural progenitor cells and brain organoids

BZ Zhang, H Chu, S Han, H Shuai, J Deng, Y Hu… - Cell research, 2020 - nature.com
… whether SARS-CoV-2 could infect 3D human brain organoids. We generated iPSC-derived
human brain organoids using previously described protocols. The 35-day-old brain

Neuroinvasion of SARS-CoV-2 in human and mouse brain

E Song, C Zhang, B Israelow, A Lu-Culligan… - Journal of Experimental …, 2021 - rupress.org
… mice, and infections of human brain organoids: that SARS-CoV-2 … , and the disruption of brain
vasculature can make vulnerable … of human brain organoids, beyond modeling fetal brains, …