[HTML][HTML] Complement alternative and mannose-binding lectin pathway activation is associated with COVID-19 mortality

F Defendi, C Leroy, O Epaulard, G Clavarino… - Frontiers in …, 2021 - frontiersin.org
activation, and the mortality in COVID-19 patients (cluster 4). Our data are in line with Ma et
al. showing increased AP components in COVID-19 … AP activity and COVID-19 severity (22). …

[HTML][HTML] Complement Activation via the Lectin and Alternative Pathway in Patients With Severe COVID-19

J Niederreiter, C Eck, T Ries, A Hartmann… - Frontiers in …, 2022 - frontiersin.org
COVID-19-induced complement activation occurred via the lectin pathway, while activation of
the alternative pathway … higher COVID-19 severity and mortality (21). However, evidence of …

[HTML][HTML] Plasma lectin pathway complement proteins in patients with COVID-19 and renal disease

NR Medjeral-Thomas, A Troldborg… - Frontiers in …, 2021 - frontiersin.org
lectin pathway contributes to COVID-19 pathogenesis, we measured the plasma concentration
of 11 lectin … Black crosses mark patient deaths. Coloured bars show when patients met …

The role of the lectin pathway of the complement system in SARS-CoV-2 lung injury

MAS Malaquias, AC Gadotti… - Translational …, 2021 - Elsevier
… Despite the excessive number of deaths resulting from the current pandemic COVID-19, very
few … Here, we described the massive activation of the lectin pathway, with consequences of …

[HTML][HTML] Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups

, … of Health Research (CITIID-NIHR) COVID … - Frontiers in …, 2023 - frontiersin.org
… Despite this, genetic variations in MBL2 are not associated with susceptibility to SARS-CoV-2
infection or disease outcomes such as mortality and the development of Long COVID. …

[HTML][HTML] The influence of the lectin pathway of complement activation on infections of the respiratory system

AS Świerzko, M Cedzyński - Frontiers in Immunology, 2020 - frontiersin.org
deaths than previously expected due to the pandemic of coronavirus disease 2019 (COVID-19), …
called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Complement …

Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab

A Rambaldi, G Gritti, MC Micò, M Frigeni, G Borleri… - Immunobiology, 2020 - Elsevier
… therapy (RECOVERY) trial, demonstrated that dexamethasone reduced 28-day mortality in
patients on invasive mechanical ventilation by 28.7 % (29.0 % versus 40.7 % with usual care)…

[HTML][HTML] Mannose-binding lectin is associated with thrombosis and coagulopathy in critically ill COVID-19 patients

O Eriksson, M Hultström, B Persson… - Thrombosis and …, 2020 - thieme-connect.com
… significant morbidity and mortality, as well … lectin pathway of complement activation, binds
to coronaviruses[5] and has been proposed to participate in the host defense during COVID-19

[HTML][HTML] Lectin pathway enzyme MASP-2 and downstream complement activation in COVID-19

MP Götz, MO Skjoedt, R Bayarri-Olmos… - Journal of Innate …, 2023 - karger.com
… of coronavirus disease 2019 (COVID-19). To study a possible association between MASP-2
and COVID-19, … Survival was evaluated by 30-day mortality, meaning a 30-day follow-up on …

[HTML][HTML] Inhibition of the lectin pathway of complement ameliorates hypocomplementemia and restores serum bactericidal activity in patients with severe COVID19

NJ Lynch, ACY Chan, YM Ali, P Khatri… - Clinical and …, 2022 - ncbi.nlm.nih.gov
… the activation of the lectin pathway ( S1 ). In March 2020, we conducted a small clinical study
using narsoplimab to treat six patients with severe COVID19… showed mortality rates of 32% …