mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits comparable B cell expansion, neutralizing antibodies and protection against Omicron
M Gagne, JI Moliva, KE Foulds, SF Andrew, BJ Flynn… - BioRxiv, 2022 - biorxiv.org
SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to antibody
neutralization following immunization with ancestral spike-matched vaccines. It is unclear
whether boosting with Omicron-specific vaccines would enhance immunity and protection.
Here, nonhuman primates that received mRNA-1273 at weeks 0 and 4 were boosted at
week 41 with mRNA-1273 or mRNA-Omicron. Neutralizing antibody titers against D614G
were 4760 and 270 reciprocal ID50 at week 6 (peak) and week 41 (pre-boost), respectively …
neutralization following immunization with ancestral spike-matched vaccines. It is unclear
whether boosting with Omicron-specific vaccines would enhance immunity and protection.
Here, nonhuman primates that received mRNA-1273 at weeks 0 and 4 were boosted at
week 41 with mRNA-1273 or mRNA-Omicron. Neutralizing antibody titers against D614G
were 4760 and 270 reciprocal ID50 at week 6 (peak) and week 41 (pre-boost), respectively …
mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron
M Gagne, JI Moliva, KE Foulds, SF Andrew, BJ Flynn… - Cell, 2022 - cell.com
SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to
neutralization following immunization with ancestral spike-matched vaccines. It is unclear
whether boosting with Omicron-matched vaccines would enhance protection. Here,
nonhuman primates that received mRNA-1273 at weeks 0 and 4 were boosted at week 41
with mRNA-1273 or mRNA-Omicron. Neutralizing titers against D614G were 4,760 and 270
reciprocal ID 50 at week 6 (peak) and week 41 (preboost), respectively, and 320 and 110 for …
neutralization following immunization with ancestral spike-matched vaccines. It is unclear
whether boosting with Omicron-matched vaccines would enhance protection. Here,
nonhuman primates that received mRNA-1273 at weeks 0 and 4 were boosted at week 41
with mRNA-1273 or mRNA-Omicron. Neutralizing titers against D614G were 4,760 and 270
reciprocal ID 50 at week 6 (peak) and week 41 (preboost), respectively, and 320 and 110 for …
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