p16 positive oropharyngeal squamous cell carcinoma: an entity with a favorable prognosis regardless of tumor HPV status
JS Lewis Jr, WL Thorstad, RD Chernock… - The American journal …, 2010 - journals.lww.com
Background In the human papillomavirus (HPV) era, the best way to assess oropharyngeal
squamous carcinomas (SCC) for risk stratification is not clear. Many recommend use of both
p16 immunohistochemistry and HPV in situ hybridization (ISH). A significant minority of
tumors are p16 positive and HPV ISH negative, the significance of which is unclear. Methods
Two hundred thirty-nine oropharyngeal SCC were tested by immunohistochemistry for p16
and by ISH for high-risk HPV. For p16 positive, HPV ISH negative cases, PCR was …
squamous carcinomas (SCC) for risk stratification is not clear. Many recommend use of both
p16 immunohistochemistry and HPV in situ hybridization (ISH). A significant minority of
tumors are p16 positive and HPV ISH negative, the significance of which is unclear. Methods
Two hundred thirty-nine oropharyngeal SCC were tested by immunohistochemistry for p16
and by ISH for high-risk HPV. For p16 positive, HPV ISH negative cases, PCR was …