pH-driven actuation of DNA origami via parallel I-motif sequences in solution and on surfaces

JM Majikes, LCC Ferraz, TH LaBean - Bioconjugate Chemistry, 2017 - ACS Publications
JM Majikes, LCC Ferraz, TH LaBean
Bioconjugate Chemistry, 2017ACS Publications
As bottom up DNA nanofabrication creates increasingly complex and dynamic mechanisms,
the implementation of actuators within the DNA nanotechnology toolkit has grown
increasingly important. One such actuator, the I-motif, is fairly simple in that it consists solely
of standard DNA sequences and does not require any modification chemistry or special
purification beyond that typical for DNA oligomer synthesis. This study presents a new
implementation of parallel I-motif actuators, emphasizing their future potential as drivers of …
As bottom up DNA nanofabrication creates increasingly complex and dynamic mechanisms, the implementation of actuators within the DNA nanotechnology toolkit has grown increasingly important. One such actuator, the I-motif, is fairly simple in that it consists solely of standard DNA sequences and does not require any modification chemistry or special purification beyond that typical for DNA oligomer synthesis. This study presents a new implementation of parallel I-motif actuators, emphasizing their future potential as drivers of complex internal motion between substructures. Here we characterize internal motion between DNA origami substructures via AFM and image analysis. Such parallel I-motif design and quantification of actuation provide a useful step toward more complex and effective molecular machines.
ACS Publications
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