Proinflammatory role of vascular endothelial growth factor in the pathogenesis of rheumatoid arthritis: prospects for therapeutic intervention

SA Yoo, SK Kwok, WU Kim - Mediators of inflammation, 2008 - Wiley Online Library
… In addition, we present a new therapy for RA based on a synthetic anti-VEGF hexapeptide
that specifically targets the interaction between VEGF and its receptor. Prospects for the …

Th22 in inflammatory and autoimmune disease: prospects for therapeutic intervention

N Zhang, HF Pan, DQ Ye - Molecular and cellular biochemistry, 2011 - Springer
… In vitro, IL-22 was found to promote osteoclastogenesis, a process that might contribute
to its proinflammatory activity in CIA [24]. The proinflammatory role of endogenous IL-22 in …

Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

K Rajasekhar, T Govindaraju - RSC advances, 2018 - pubs.rsc.org
… tools for diagnostic and therapeutic interventions that target … Challenges and future prospects
include the integration of … the pro-inflammatory cytokine TNF-α and prevents its function

Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components

H Martin - … Research/Fundamental and Molecular Mechanisms of …, 2009 - Elsevier
… The prospects for dietary intervention in … the pro-inflammatory cytokines, IL6 and IL8, reduced
by these PUFAs, but the expression of PPARγ was itself enhanced [44]. The central role of …

Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects

R Dharra, AK Sharma, S Datta - Cytokine, 2023 - Elsevier
… describe the role of various cytokines in COVID-19-associated CS. We will particularly
emphasize the role of GM-CSF and G-CSF cytokines and other emerging therapeutic strategies …

Insulin resistance as a proinflammatory state: mechanisms, mediators, and therapeutic interventions

R Garg, D Tripathy, P Dandona - Current drug targets, 2003 - ingentaconnect.com
… disease and the evolving therapeutic interventions. … concentration is likely to be proinflammatory
and thus potentially harmful. … The possibilities appear to be immense and promising. …

Present concepts and future outlook: function of peroxisome proliferator‐activated receptors (PPARs) for pathogenesis, progression, and therapy of cancer

P Sertznig, M Seifert, W Tilgen… - Journal of cellular …, 2007 - Wiley Online Library
… cancer prevention and treatment. PPAR ligands … roles of PPARs in relation to the processes
of cell differentiation and carcinogenesis as well as their role as promising future therapeutic

Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect?

P Welsh, G Grassia, S Botha, N Sattar… - British journal of …, 2017 - Wiley Online Library
… In this review, we discuss key therapeutic targets in the treatment of vascular inflammation,
placing basic research in a wider clinical perspective, as well as identifying outstanding …

Future prospects of anticytokine therapy in chronic heart failure

S von Haehling, SD Anker - Expert Opinion on Investigational …, 2005 - Taylor & Francis
… Most attention has so far focussed on the role of pro-inflammatory cytokines, especially that
of TNF-α, and IL-1 and -6. The origin of elevated levels of these substances is not yet clear; …

Prostanoids in tumor angiogenesis: therapeutic intervention beyond COX-2

MD Salvado, A Alfranca, JZ Haeggström… - Trends in molecular …, 2012 - cell.com
… Here, we discuss the role of prostanoids as modulators of tumor angiogenesis and how
prostanoid … Finally, we discuss the potential of new NSAIDs for the treatment of angiogenesis-…