Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

DS Khoury, D Cromer, A Reynaldi, TE Schlub… - Nature medicine, 2021 - nature.com
… To further dissect the relationship between immunogenicity and protection in SARS-CoV-2
we considered the parallels with previous approaches to estimating a ‘50% protective titer’ in …

Antibody titers and protection against a SARS-CoV-2 infection

C Dimeglio, F Herin, G Martin-Blondel… - Journal of …, 2022 - journalofinfection.com
… neutralizing antibodies are considered linked to protective immunity … antibodies after
vaccination without being able to provide a threshold below which protection against SARS-CoV-2

[HTML][HTML] Correlates of protection from SARS-CoV-2 infection

F Krammer - Lancet (London, England), 2021 - ncbi.nlm.nih.gov
… 1704 infections occurred in the naive cohort, while two … possible (two positive PCR results
90 days apart or an antibody-… first antibody positive test) infections occurred in the SARS-CoV-2

Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis

D Cromer, M Steain, A Reynaldi, TE Schlub… - The Lancet …, 2022 - thelancet.com
… of protection from symptomatic infection with a similar virus. Here we extend that work to
show that neutralising antibodies are also highly predictive of protection from SARS-CoV-2

Potently neutralizing and protective human antibodies against SARS-CoV-2

SJ Zost, P Gilchuk, JB Case, E Binshtein, RE Chen… - Nature, 2020 - nature.com
… to offer greater resistance to SARS-CoV-2 escape than single antibodies. Our results provide
a … antibodies as candidates for use as COVID-19 immunotherapeutic agents in humans. …

Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

A Schäfer, F Muecksch, JCC Lorenzi, SR Leist… - Journal of Experimental …, 2020 - rupress.org
SARS-CoV-2 S RBD would affect antibody neutralization, we used HIV-1 virus pseudotyped
with the SARS-CoV-2-MA … contributes to optimal protection against SARS-CoV-2 MA in vivo. …

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

TF Rogers, F Zhao, D Huang, N Beutler, A Burns, W He… - Science, 2020 - science.org
antibodies (4). Here, we present the isolation of highly potent nAbs to SARS-CoV-2 and
demonstrate their in vivo protective … To investigate the antibody response against SARS-CoV-2

A perspective on potential antibody-dependent enhancement of SARS-CoV-2

AM Arvin, K Fink, MA Schmid, A Cathcart, R Spreafico… - Nature, 2020 - nature.com
… First, comprehensive studies are urgently needed to define clinical correlates of protective
immunity against SARS-CoV-2. Second, because ADE of disease cannot be reliably predicted …

Correlates of protection against SARSCoV2 infection and COVID19 disease

D Goldblatt, G Alter, S Crotty… - Immunological reviews, 2022 - Wiley Online Library
… Although evidence for the primacy of those antibodies for protection will be presented below,
… of the antibody are required for protection against SARS-CoV-2 has been poorly studied. …

WHO international standard for SARS-CoV-2 antibodies to determine markers of protection

F Zhu, T Althaus, CW Tan, A Costantini, WN Chia… - The Lancet …, 2022 - thelancet.com
antibody level is a good biomarker for the correlate of protection against SARS-CoV-2 … of
the interaction between the SARS-CoV-2 spike protein and the angiotensin-converting enzyme …